C3sc52806e 501..506
نویسندگان
چکیده
The Z-selective cross metathesis of allylic-substituted olefins is explored with recently developed ruthenium-based metathesis catalysts. The reaction proceeds with excellent stereoselectivity for the Zisomer (typically >95%) and yields of up to 88% for a variety of allylic substituents. This includes the first synthesis of Z-a,b-unsaturated acetals by cross metathesis and their elaboration to Z-a,b-unsaturated aldehydes. In addition, the reaction is tolerant of a variety of cross partners, varying in functionality and steric profile.
منابع مشابه
IN VITRO METABOLISM OF A NEW ANTICANCER AGENT, 6-N-FORMYLAMINO-12,13- DIHYDRO-1,11-DIHYDROXY-13-(b-D-GLUCOPYRANOSIL)5H-INDOLO [2,3-A]PYRROLO [3,4-C]CARBAZOLE-5,7(6H)-DIONE (NB-506), IN MICE, RATS, DOGS, AND HUMANS
The metabolism of 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(b-D-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506), a potent inhibitor of DNA topoisomerase I, was characterized in mice, rats, dogs, and humans in vitro. NB-506 was deformylated to ED-501 in mouse and rat plasma with enzyme activity of 140 and 116 pmol/min/mg protein, respectively. The enzyme ac...
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DuBell, W. H., S. T. Gaa, W. J. Lederer, and T. B. Rogers. Independent inhibition of calcineurin and K1 currents by the immunosuppressant FK-506 in rat ventricle. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H2041–H2052, 1998.—FK-506 increases the cytosolic Ca21 concentration transient in rat ventricular myocytes by prolonging the action potential through inhibition of the K1 currents Ito and...
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CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Correspondence: Seon Young Park, MD Department of Internal Medicine, Chonnam National U...
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